Historic Commercial Street logo for C-Street in Springfield, Missouri
Brew 21 Extra Chromosome Coffee Co. logo, a mission-driven coffee shop on Historic C-Street.

Brew 21 Extra Chromosome Coffee

Brew 21 Extra Chromosome Coffee Co. is a locally owned coffee shop inside Upside Down Mercantile on Springfield’s Historic C-Street. Founded by Chris and Whitney Justis, it serves espresso drinks, roasted coffee, baked goods, and take-home beans while creating meaningful employment opportunities for young adults with disabilities. 

Visitors can expect a cheerful, inclusive space for coffee, conversation, and browsing the surrounding mercantile. The shop offers both classic and specialty drinks while giving guests an opportunity to support a business centered on purpose, community, and meaningful work.

209 W Commercial St, Springfield, MO 65803
417 693-2498
  • Sunday: Closed
  • Monday: Closed
  • Tuesday: Closed
  • Wednesday: 8:00 am – 2:00 pm
  • Thursday: 8:00 am – 2:00 pm
  • Friday: 8:00 am – 2:00 pm
  • Saturday: 8:00 am – 2:00 pm